Mononitrato de Isosorbida [Spanish]
Brand names,
Mononitrato de Isosorbida [Spanish]
Analogs
Mononitrato de Isosorbida [Spanish]
Brand Names Mixture
Mononitrato de Isosorbida [Spanish]
Chemical_Formula
C6H9NO6
Mononitrato de Isosorbida [Spanish]
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Mononitrato de Isosorbida [Spanish]
fda sheet
Mononitrato de Isosorbida [Spanish]
msds (material safety sheet)
Mononitrato de Isosorbida [Spanish]
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Mononitrato de Isosorbida [Spanish]
Molecular Weight
191.139 g/mol
Mononitrato de Isosorbida [Spanish]
Melting Point
88-91oC
Mononitrato de Isosorbida [Spanish]
H2O Solubility
1.07E+005 mg/L
Mononitrato de Isosorbida [Spanish]
State
Solid
Mononitrato de Isosorbida [Spanish]
LogP
-0.15
Mononitrato de Isosorbida [Spanish]
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Mononitrato de Isosorbida [Spanish]
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Mononitrato de Isosorbida [Spanish]
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Mononitrato de Isosorbida [Spanish]
Absorption
100%
Mononitrato de Isosorbida [Spanish]
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Mononitrato de Isosorbida [Spanish]
Patient Information
Mononitrato de Isosorbida [Spanish]
Organisms Affected
Humans and other mammals